On a three-night trip the first and last days are mostly travel, which leaves about two full sightseeing days. That favors hotels close to the station you arrive at and hotels that let you keep each day within either Namba or Umeda. Families should compare room count and bed setup before the hotel name, and large hotels give more room combinations when a party splits across two rooms. Luggage storage after checkout matters most when the flight home is in the afternoon.
From Kansai Airport, compare Namba via Nankai and Umeda via airport bus or rail transfers. Namba and Shinsaibashi keep Dotonbori and Kuromon Market walkable; Umeda suits Kyoto, Kobe, Nara and airport connections.
Day one usually starts with the Nankai line or an airport bus from Kansai Airport and an evening walk right after check-in. Day two tends to go to either a walk through Namba or a day trip to Kyoto, and day three to USJ or shopping in Umeda before a morning return to the airport. Staying put in one hotel means no luggage moves between nights.
Check the room type and maximum occupancy, breakfast, accommodation or bathing taxes, free-cancellation deadline and early check-in or late check-out terms in the product details.