Good to know before you book
Thong Lo sits on the BTS Sukhumvit Line, making it easy to travel in one direction towards Phrom Phong, Asok and Siam and in the other towards Ekkamai and On Nut. That is useful when a Bangkok itinerary mixes shopping, meals and activities in different areas. BTS and MRT are separate systems, so allow a little extra time if you plan to change at Asok.
When comparing hotels near Thong Lo, separate the neighbourhood name from the distance to the station. The liveliest parts of Soi 55 can be well inside the street, while Soi 57 is more directly connected to the station exit. Check the soi number as well as the hotel name if an easy walk home after dinner matters to you.
Hotel Nikko Bangkok is a particularly straightforward choice for a first arrival or a BTS-heavy itinerary: the hotel says it is about two minutes from Thong Lo Exit 1. Boutique hotels on Sukhumvit 53 and 57 may involve a little more walking, but can make more sense when the hotel atmosphere, dining and a quieter side street are part of the stay.
Thong Lo is often chosen for cafés by day and restaurants or bars in the evening. Even if your hotel is close to the station, your chosen venue may be further into a soi. Before you book, join the BTS exit, hotel entrance and dinner plans on a map; rain and luggage make that small check worthwhile.
For a family or group trip, do not let station access decide the room on its own. Bed layouts, extra-bed charges, breakfast rules and connecting-room availability differ by room type. The train can simplify the city days, but the product page is where you should confirm how everyone will actually sleep.